Bullman T A, Watanabe K K, Kang H K
Environmental Epidemiology Service, Department of Veterans Affairs, Washington, DC 20036-3406.
Ann Epidemiol. 1994 Jan;4(1):11-6. doi: 10.1016/1047-2797(94)90037-x.
A case-control analysis was undertaken to examine the association between various surrogate measures of Agent Orange exposure and testicular cancer among Vietnam veterans. Study subjects were selected from the Department of Veterans Affairs Agent Orange Registry. The case patients consisted of 97 veterans with a diagnosis of testicular cancer, and 311 veterans without any clinical diagnosis served as a comparison group. The surrogate measures were branch of service, type of duty, corps area, and location of the individual's unit in relation to recorded Agent Orange spray tracts. Only Navy veterans had a statistically significant increased risk of testicular cancer (odds ratio (OR) = 2.60; 95% confidence interval (CI), 1.08 to 6.24). Risk of testicular cancer was not significantly increased for ground troops (OR = 0.46; 95% CI, 0.25 to 0.86), for combat duty (OR = 0.91; 95% CI, 0.52 to 1.58), for service in the III Corps area (OR = 1.10; 95% CI, 0.66 to 1.84), and for being close to spray tracts within 90 days/8 km (OR = 0.99; 95% CI, 0.54 to 1.84) or 3 days/2 km (OR = 1.39; 95% CI, 0.50 to 3.80). The study results are not consistent with the hypothesis that Agent Orange may be a risk factor for testicular cancer among Vietnam veterans.
进行了一项病例对照分析，以研究越战老兵中各种橙剂接触替代指标与睾丸癌之间的关联。研究对象选自退伍军人事务部橙剂登记处。病例组由97名被诊断患有睾丸癌的老兵组成，311名无任何临床诊断的老兵作为对照组。替代指标包括服役分支、任务类型、军区以及个人所在单位相对于记录的橙剂喷洒区域的位置。只有海军老兵患睾丸癌的风险有统计学意义的显著增加（优势比（OR）=2.60；95%置信区间（CI），1.08至6.24）。地面部队（OR = 0.46；95% CI，0.25至0.86）、执行战斗任务（OR = 0.91；95% CI，0.52至1.58）、在第三军区服役（OR = 1.10；95% CI，0.66至1.84）以及在90天/8公里（OR = 0.99；95% CI，0.54至1.84）或3天/2公里（OR = 1.39；95% CI，0.50至3.80）范围内靠近喷洒区域的情况下，患睾丸癌的风险没有显著增加。研究结果与橙剂可能是越战老兵睾丸癌风险因素的假设不一致。
