Dobbie J W, Tasiaux N, Meijers P, Anderson J D, Bodart C, Hind C, Bourguet C, Perret J
Baxter R&D Europe, Nivelles, Belgium.
Br J Rheumatol. 1994 Jun;33(6):508-19. doi: 10.1093/rheumatology/33.6.508.
Intracytoplasmic lamellar organelles identical in ultrastructure to surfactant-containing lamellar bodies found in type II pneumocytes, have been demonstrated in other tissues, in synoviocytes and mesothelial cells, in a distribution pattern which reflects the systemic expression of rheumatoid disease. Antibodies raised against surfactant protein A (SP-A), exhibit a ranking of tissue reactivity in area, intensity and density of cells which also parallels the frequency and degree of pathological involvement characteristic of rheumatoid disease, showing in ascending order of immunopositivity, lacrymal and salivary epithelia, pulmonary parenchyma, mesothelium and synoviocytes. Maximal tissue reactivity to anti-SP-A antibodies was found in the synovium of 55 rheumatoid patients exhibiting classical histopathological appearances of RA, in a pattern of immunostaining identical to that obtained with ML30, an antibody to mycobacterial heat shock protein 65kDa which, in turn, cross-reacted with SP-A in dot blot testing.
在其他组织中，如滑膜细胞和间皮细胞中，已证实存在超微结构与II型肺细胞中含表面活性物质的板层小体相同的胞质内板层细胞器，其分布模式反映了类风湿性疾病的全身表达。针对表面活性蛋白A（SP-A）产生的抗体，在细胞面积、强度和密度方面表现出组织反应性的排序，这也与类风湿性疾病的病理累及频率和程度平行，免疫阳性呈升序排列的是泪腺和唾液腺上皮、肺实质、间皮和滑膜细胞。在55例表现出类风湿性关节炎典型组织病理学表现的类风湿患者的滑膜中，发现对抗SP-A抗体的组织反应性最强，其免疫染色模式与用ML30获得的模式相同，ML30是一种针对结核分枝杆菌热休克蛋白65kDa的抗体，在斑点印迹试验中，该抗体又与SP-A发生交叉反应。
