Illingworth D R
Department of Medicine, Oregon Health Sciences University, Portland.
Clin Ther. 1994 Jan-Feb;16(1):2-26; discussion 1.
The present review discusses the mechanism of action, efficacy, safety profile, and potential uses of lovastatin in patients with hypercholesterolemia. Data on the efficacy of lovastatin are evaluated in different patient populations; also, the efficacy of this agent in the long-term treatment of patients followed by the author is presented. No new safety concerns have emerged during long-term treatment of selected patients with lovastatin, and, in compliant patients, hypolipidemic effects are maintained during continuous treatment with therapy that exceeds 5 years. On the basis of available data, lovastatin should be regarded as one of the drugs of first choice in the treatment of adult patients with hypercholesterolemia and increased plasma concentrations of low-density lipoproteins.
本综述讨论了洛伐他汀在高胆固醇血症患者中的作用机制、疗效、安全性概况及潜在用途。对洛伐他汀在不同患者群体中的疗效数据进行了评估；此外，还介绍了作者随访的患者长期使用该药的疗效。在对选定患者进行洛伐他汀长期治疗期间未出现新的安全问题，并且在依从性良好的患者中，超过5年的持续治疗期间血脂降低作用得以维持。根据现有数据，洛伐他汀应被视为治疗成人高胆固醇血症和低密度脂蛋白血浆浓度升高患者的首选药物之一。
