Aken'Ova Y A, Campbell O B
Department of Haematology, University College Hospital, Ibadan.
Cent Afr J Med. 1993 Jul;39(7):133-6.
Chronic myelogenous leukaemia (CML) in Nigerians shows a male predominance over females as has been observed in other centres. Out of 25 patients treated between 1987 and 1990, 18 were male. The mean survival of CML patients on chemotherapy was 48.7 months with a median of 38 months, while the mean survival of patients who had chemotherapy plus splenic irradiation was 53.3 months with a median survival of 53 months. The difference between the two mean survival rates was non-significant. Splenic irradiation resulted in significant reduction in splenic size with total disappearance of gastrointestinal symptoms. The need for red cell and blood products transfusion diminished. Patients had a feeling of well being though short-lived. In a developing country, the added cost of irradiation must be weighted against the relatively brief improvement in well-being when deciding mode of management of the disease. Cause of death in all cases was septicaemia, complications of thrombocytopaenia and marrow failure.
与其他中心观察到的情况一样，尼日利亚的慢性粒细胞白血病（CML）患者中男性多于女性。在1987年至1990年期间接受治疗的25例患者中，有18例为男性。接受化疗的CML患者的平均生存期为48.7个月，中位数为38个月，而接受化疗加脾照射的患者的平均生存期为53.3个月，中位生存期为53个月。两种平均生存率之间的差异无统计学意义。脾照射导致脾脏大小显著缩小，胃肠道症状完全消失。红细胞和血液制品输血的需求减少。患者有幸福感，尽管持续时间较短。在发展中国家，在决定该疾病的治疗方式时，必须权衡照射增加的成本与幸福感相对短暂的改善。所有病例的死因均为败血症、血小板减少症并发症和骨髓衰竭。
