Steinke W, Els T, Hennerici M
Department of Neurology, University of Heidelberg, Klinikum Mannheim, Germany.
Circulation. 1994 Jun;89(6):2578-81. doi: 10.1161/01.cir.89.6.2578.
From pathological studies of coronary arteries, it has been recognized that progressive plaque development may be compensated for by an increase of the arterial diameter. However, the dynamics of this process have not been investigated, and it is not known whether compensatory dilatation is a general pathomechanism in human arteries.
Using a high-resolution duplex scanner and subsequent three-dimensional plaque reconstruction, we prospectively studied the effect of carotid plaque development on the vascular geometry in 32 patients at 6- to 12-month intervals. Plaque progression in 41% (n = 26) of studies was associated with an increase of the vessel diameter between 0.4 and 1.2 mm in 76% (n = 20). Among 36 unchanged plaque developments, enlargement of the arterial diameter was assessed in only 28% (n = 10) (P < .001).
Our data suggest that increasing plaque volume is significantly associated with enlargement of carotid artery segments, which compensates for arterial narrowing in early stages of the disease.
通过冠状动脉的病理研究发现，动脉直径的增加可能会补偿斑块的进展。然而，这一过程的动态变化尚未得到研究，补偿性扩张是否是人类动脉的普遍病理机制也尚不清楚。
我们使用高分辨率双功扫描仪及后续的三维斑块重建技术，对32例患者每隔6至12个月进行前瞻性研究，观察颈动脉斑块进展对血管几何形态的影响。在41%（n = 26）的研究中，斑块进展与血管直径增加0.4至1.2毫米相关，其中76%（n = 20）出现这种情况。在36例斑块无变化的研究中，只有28%（n = 10）观察到动脉直径增大（P <.001）。
我们的数据表明，斑块体积增加与颈动脉节段扩张显著相关，这在疾病早期可补偿动脉狭窄。
