Robert Caroline, Tan Wei Ying, Ling Lieng-Hsi, Hilal Saima
Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore.
Saw Swee Hock School of Public Health National University of Singapore and National University Health System Singapore Singapore.
Alzheimers Dement (Amst). 2025 Jan 29;17(1):e70069. doi: 10.1002/dad2.70069. eCollection 2025 Jan-Mar.
We examined the associations of carotid intima-media thickness (CIMT), arterial stiffness index (ASI), and pulse pressure (PP) with cerebrovascular disease, cognitive function and decline, and incident cardiovascular diseases (CVD) and dementia in the UK Biobank cohort.
The study consisted of 42,711 participants (mean age 64.2 years) with brain magnetic resonance imaging (MRI), vascular assessments, and cognitive testing. Cerebrovascular disease markers included white matter hyperintensities (WMH) and brain volumes. CIMT, ASI, and PP were measured using carotid ultrasound, photoplethysmography, and blood pressure, respectively. General cognitive ability (-score) was derived from various cognitive tests using principal components analysis (PCA).
Elevated CIMT, ASI, and PP were associated with increased WMH volume (WMHV). Increased PP was independently associated with poorer numeric memory ( = -0.028, = 0.002), fluid intelligence (IQ) ( = -0.060, < 0.001), and -score ( = -0.028, < 0.001) in cross-sectional analysis, but not longitudinally. CIMT showed the strongest association with incident CVD and dementia.
CIMT had the most robust associations with WMHV, incident CVD, and dementia, suggesting its utility as an alternative endpoint.
Effects of arterial stiffness on cognition, dementia, and CVD.Structural vascular parameters included CIMT.Functional properties included ASI and PP.CIMT, ASI, and PP were positively associated with WMHV.CIMT had the greatest associations with incident CVD and dementia.
我们在英国生物银行队列中研究了颈动脉内膜中层厚度（CIMT）、动脉僵硬度指数（ASI）和脉压（PP）与脑血管疾病、认知功能及衰退、心血管疾病（CVD）和痴呆症发病之间的关联。
该研究纳入了42711名参与者（平均年龄64.2岁），他们均接受了脑磁共振成像（MRI）、血管评估和认知测试。脑血管疾病标志物包括白质高信号（WMH）和脑容量。CIMT、ASI和PP分别通过颈动脉超声、光电容积描记法和血压测量得出。一般认知能力（得分）通过主成分分析（PCA）从各种认知测试中得出。
CIMT、ASI和PP升高与WMH体积（WMHV）增加相关。在横断面分析中，PP升高与较差的数字记忆（β = -0.028，P = 0.002）、流体智力（IQ）（β = -0.060，P < 0.001）和得分（β = -0.028，P < 0.001）独立相关，但在纵向分析中无此关联。CIMT与CVD和痴呆症发病的关联最为强烈。
CIMT与WMHV、CVD和痴呆症发病的关联最为显著，表明其可用作替代终点。
动脉僵硬度对认知、痴呆症和CVD的影响。结构血管参数包括CIMT。功能特性包括ASI和PP。CIMT、ASI和PP与WMHV呈正相关。CIMT与CVD和痴呆症发病的关联最为显著。
