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[高剂量静脉注射7S免疫球蛋白在HIV相关免疫病理学中的应用]

[The use of intravenous 7S immunoglobulins at high doses in HIV-related immunological pathology].

作者信息

Fiori G P

机构信息

Divisione di Malattie Infettive, Ospedale Multizonale di Varese.

出版信息

Clin Ter. 1994 Apr;144(4):301-5.

PMID:8205754
Abstract

24 AIDS patients, both males and females, aged from 3 to 52 years, received high-dose i.v. 7S immunoglobulin (220-400 mg/kg, range 7.5-20 g/die). These patients were affected by HIV-related thrombocytopenia and antibiotic-resistant severe hyperpyrexia; three HIV-positive asymptomatic children with severe immunodeficiency were treated to prevent opportunistic infections. I.V. 7S immunoglobulins were well tolerated, and were found to be very effective in the therapy of thrombocytopenia and in the prevention of opportunistic infections in the asymptomatic children.

摘要

24名年龄在3至52岁之间的艾滋病患者(男女均有)接受了大剂量静脉注射7S免疫球蛋白(220 - 400毫克/千克,范围为7.5 - 20克/日)。这些患者患有与HIV相关的血小板减少症以及对抗生素耐药的严重高热;对三名患有严重免疫缺陷的HIV阳性无症状儿童进行治疗以预防机会性感染。静脉注射7S免疫球蛋白耐受性良好,并且发现在治疗血小板减少症以及预防无症状儿童的机会性感染方面非常有效。

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