Wendt M, Fuhrmann H, Damsch S
Klinik für kleine Klauentiere und forensische Medizin, Tierärztlichen Hochschule Hannover.
Dtsch Tierarztl Wochenschr. 1994 Apr;101(4):141-5.
Experimentally induced salinomycin toxicosis in weanling pigs showed typical clinical signs of an intoxication with a polyether antibiotic. Severe ataxia and recumbency were the most prominent symptoms, which could be attributed to acute skeletal muscle necrosis by estimation of muscle enzyme activities (creatine kinase, aspartate aminotransferase) and histopathological examination. Intoxication had neither influence on concentrations of vitamin E and selenium-dependent glutathione peroxidase in plasma and different organs nor on contents of fatty acids in skeletal muscles. No signs of increased lipid peroxidation in muscle tissue could be found. Prophylactic application of vitamin E or selenium one day before administration of salinomycin as well as treatment on the following days produced no protective effects. The treated pigs showed equal clinical and pathomorphological alterations as the untreated animals, although applications caused a significant increase of alpha-tocopherol and glutathione peroxidase concentrations in blood and different organs.
在断奶仔猪中进行的实验性盐霉素中毒显示出聚醚类抗生素中毒的典型临床症状。严重共济失调和卧地不起是最突出的症状，通过测定肌肉酶活性（肌酸激酶、天冬氨酸氨基转移酶）和组织病理学检查，可归因于急性骨骼肌坏死。中毒对血浆和不同器官中维生素E和硒依赖性谷胱甘肽过氧化物酶的浓度以及骨骼肌中脂肪酸的含量均无影响。在肌肉组织中未发现脂质过氧化增加的迹象。在给予盐霉素前一天预防性应用维生素E或硒以及在随后几天进行治疗均未产生保护作用。尽管用药导致血液和不同器官中α-生育酚和谷胱甘肽过氧化物酶浓度显著升高，但治疗组猪与未治疗动物表现出相同的临床和病理形态学改变。
