Gadducci A, Baicchi U, Marrai R, Del Bravo B, Fosella P V, Facchini V
Department of Gynecology and Obstetrics, University of Pisa, Italy.
Gynecol Oncol. 1994 Jun;53(3):352-6. doi: 10.1006/gyno.1994.1146.
The preoperative plasma levels of fibrinopeptide-A (FPA), D-dimer (DD), and von Willebrand Factor (vWF) were measured in 125 patients with ovarian masses undergoing laparotomy and in 88 healthy nonpregnant women as controls. FPA, DD, and vWF levels were significantly higher in the 58 patients with ovarian carcinoma than in the 67 patients with benign ovarian disease or controls. FPA and DD values were significantly higher in advanced (FIGO stage III-IV) than in early ovarian carcinoma. Among patients with advanced disease, FPA and DD levels correlated with none of the common clinicopathological prognostic variables; conversely, vWF values were related to FIGO stage (IV versus III, P < 0.02) and size of residual disease after initial surgery (> 2 cm versus < or = 2 cm, P < 0.05). In conclusion, increased fibrin production and degradation occur in patients with ovarian carcinoma.
对125例接受剖腹手术的卵巢肿块患者及88例健康未孕女性作为对照，测定术前血浆纤维蛋白肽A（FPA）、D - 二聚体（DD）和血管性血友病因子（vWF）水平。58例卵巢癌患者的FPA、DD和vWF水平显著高于67例良性卵巢疾病患者或对照组。晚期（国际妇产科联盟[FIGO]分期III - IV期）卵巢癌患者的FPA和DD值显著高于早期卵巢癌患者。在晚期疾病患者中，FPA和DD水平与任何常见的临床病理预后变量均无相关性；相反，vWF值与FIGO分期（IV期与III期，P < 0.02）及初次手术后残留病灶大小（> 2 cm与≤ 2 cm，P < 0.05）有关。总之，卵巢癌患者存在纤维蛋白生成和降解增加的情况。
