Van Nostrand K M, Lucci J A, Liao S Y, Di Saia P J
Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange 92668.
Gynecol Oncol. 1994 Jun;53(3):361-5. doi: 10.1006/gyno.1994.1148.
Primary lung choriocarcinoma has rarely been reported. In females, previous pregnancies and other sources of trophoblastic tissue such as a nongestational gonadal choriocarcinoma must be excluded before the diagnosis can be made. Here we present a young female patient initially diagnosed as having a metastatic gestational neoplasm who was unresponsive to standard single and multiagent chemotherapy. A total abdominal hysterectomy and bilateral salpingo-oopherectomy failed to reveal the source of production of beta HCG. At the time of her thoracotomy and lobectomy, performed for a lung nodule, she was found to have a primary lung choriocarcinoma. The patient received no further chemotherapy and has remained disease free for more than 3 years. This is the first recorded case of a lung choriocarcinoma that has been successfully treated where the patient has remained free of disease for more than 1 year.
原发性肺绒毛膜癌鲜有报道。对于女性患者，在做出诊断之前，必须排除既往妊娠及其他滋养层组织来源，如非妊娠性性腺绒毛膜癌。本文报告了一名年轻女性患者，最初被诊断为转移性妊娠肿瘤，对标准的单药和多药化疗均无反应。全腹子宫切除术和双侧输卵管卵巢切除术未能发现β-HCG的产生来源。在因肺结节行开胸肺叶切除术时，发现她患有原发性肺绒毛膜癌。该患者未接受进一步化疗，至今已无病生存3年多。这是首例有记录的成功治疗且无病生存超过1年的肺绒毛膜癌病例。
