Deftos L J, Lorenzi M, Bohanon N, Tsalakian E, Schneider V, Gerich J E
J Clin Endocrinol Metab. 1976 Jul;43(1):205-7. doi: 10.1210/jcem-43-1-205.
The effect of somatostatin on plasma parathyroid hormone (PTH) was studied in 6 subjects with normal parathyroid function and one patient with a parathyroid adenoma. In 5 subjects, including the one with the parathyroid adenoma, plasma PTH was measured by radioimmunoassay during a 4-hour infusion of somatostatin (500 mug/h). In 2 subjects, PTH responses to EDTA were compared with those observed during a simultaneous infusion of somatostatin and EDTA. In no instance was ther a discernible effect of the somatostatin infusion on plasma PTH. These results demonstrate that somatostatin does not suppress plasma PTH.
在6名甲状旁腺功能正常的受试者和1名甲状旁腺腺瘤患者中研究了生长抑素对血浆甲状旁腺激素(PTH)的影响。在5名受试者(包括那名甲状旁腺腺瘤患者)中,通过放射免疫分析法在4小时输注生长抑素(500微克/小时)期间测量血浆PTH。在2名受试者中,将PTH对乙二胺四乙酸(EDTA)的反应与在同时输注生长抑素和EDTA期间观察到的反应进行比较。在任何情况下,生长抑素输注对血浆PTH均无明显影响。这些结果表明,生长抑素不会抑制血浆PTH。