Nicod P, Burger A, Strauch G, Vagenakis A G, Braverman L E
J Clin Endocrinol Metab. 1976 Aug;43(2):478-81. doi: 10.1210/jcem-43-2-478.
Reverse T3 (3,3',5'-triiodothyronine, rT3), a major product of the peripheral monodeiodination of thyroxine (T4), was administered to normal male volunteers in doses sufficient to sustain an elevated serum rT3 concentration similar to that frequently observed in patients with nonthyroidal illness. No changes in basal serum T4, T3, TSH and prolactin concentrations, nor in the T3, TSH and prolactin responses to iv TRH were observed during rT3 administration. These findings suggest that physiologic increases in serum rT3 concentration probably do not inhibit T4 to T3 conversion or the anterior pituitary TSH and prolactin responses to thyrotropin-releasing hormone (TRH).
反式三碘甲状腺原氨酸（3,3',5'-三碘甲状腺原氨酸，rT3）是甲状腺素（T4）外周单碘化的主要产物，以足以维持血清rT3浓度升高的剂量给予正常男性志愿者，该浓度类似于在非甲状腺疾病患者中经常观察到的浓度。在给予rT3期间，未观察到基础血清T4、T3、促甲状腺激素（TSH）和催乳素浓度的变化，也未观察到T3、TSH和催乳素对静脉注射促甲状腺激素释放激素（TRH）的反应变化。这些发现表明，血清rT3浓度的生理性升高可能不会抑制T4向T3的转化，也不会抑制垂体前叶TSH和催乳素对促甲状腺激素释放激素（TRH）的反应。
