碘甲状腺原氨酸对离体大鼠肾小管中甲状腺素转化为3,3',5'-三碘甲状腺原氨酸的影响。
The effect of iodothyronines on the conversion of thyroxine into 3,3'-5-tri-iodothyronine in isolated rat renal tubules.
作者信息
Heyma P, Larkins R G, Campbell D G
出版信息
Biochem J. 1980 Aug 15;190(2):239-42. doi: 10.1042/bj1900239.
Abstract
Isolated rat renal tubules prepared by collagenase digestion were used to study the effects of 3,3',5'-tri-iodothyronine ('reverse T3', rT3) and other iodothyronines on the formation of 3,3',5-tri-iodothyronine (T3) from thyroxine (T4). rT3 inhibited the conversion with a dose response over the concentration range 1.5nM-1.5microM. The inhibition was competitive in nature. Both 3,3'-di-iodothyronine and 3',5'-di-iodothyronine also inhibited the production of T3 and T4 in isolated rat renal tubules, but tetraiodothyroacetic acid and 3,5-di-iodothyronine were found to have no effect. These experiments demonstrate in an intact cell system that some naturally occurring iodothyronines have significant effects on T4 deiodination.
摘要
通过胶原酶消化制备的离体大鼠肾小管用于研究3,3',5'-三碘甲状腺原氨酸（“反式T3”，rT3）和其他碘甲状腺原氨酸对甲状腺素（T4）生成3,3',5'-三碘甲状腺原氨酸（T3）的影响。rT3在1.5nM - 1.5μM的浓度范围内呈剂量依赖性抑制这种转化。这种抑制本质上是竞争性的。3,3'-二碘甲状腺原氨酸和3',5'-二碘甲状腺原氨酸也抑制离体大鼠肾小管中T3和T4的生成，但发现四碘甲状腺乙酸和3,5-二碘甲状腺原氨酸无作用。这些实验在完整细胞系统中证明，一些天然存在的碘甲状腺原氨酸对T4脱碘有显著影响。
相似文献
1
The effect of iodothyronines on the conversion of thyroxine into 3,3'-5-tri-iodothyronine in isolated rat renal tubules.碘甲状腺原氨酸对离体大鼠肾小管中甲状腺素转化为3,3',5'-三碘甲状腺原氨酸的影响。
Biochem J. 1980 Aug 15;190(2):239-42. doi: 10.1042/bj1900239.
2
The formation of tri-iodothyronine and reverse tri-iodothyronine from thyroxine in isolated rat renal tubules.在分离的大鼠肾小管中由甲状腺素形成三碘甲状腺原氨酸和反式三碘甲状腺原氨酸。
Clin Sci Mol Med Suppl. 1978 Dec;55(6):567-72. doi: 10.1042/cs0550567.
3
Glucocorticoids decrease in conversion of thyroxine into 3, 5, 3'-tri-iodothyronine by isolated rat renal tubules.糖皮质激素可降低大鼠离体肾小管将甲状腺素转化为3,5,3'-三碘甲状腺原氨酸的能力。
Clin Sci (Lond). 1982 Feb;62(2):215-20. doi: 10.1042/cs0620215.
4
pH-dependency of iodothyronine metabolism in isolated perfused rat liver.离体灌注大鼠肝脏中碘甲状腺原氨酸代谢的pH依赖性
Biochem J. 1982 Mar 15;202(3):667-75. doi: 10.1042/bj2020667.
5
Comparison of inhibitory effects of 3,5,3'-triiodothyronine (T3), thyroxine (T4), 3,3,',5'-triiodothyronine (rT3), and 3,3'-diiodothyronine (T2) on thyrotropin-releasing hormone-induced release of thyrotropin in the rat in vitro.3,5,3'-三碘甲状腺原氨酸（T3）、甲状腺素（T4）、3,3',5'-三碘甲状腺原氨酸（反T3，rT3）和3,3'-二碘甲状腺原氨酸（T2）对大鼠体外促甲状腺激素释放激素诱导的促甲状腺激素释放抑制作用的比较。
Endocrinology. 1978 Aug;103(2):393-402. doi: 10.1210/endo-103-2-393.
6
Kinetics of enzymic reductive deiodination of iodothyronines. Effect of pH.甲状腺素酶促还原脱碘动力学。pH值的影响。
Biochem J. 1979 Jun 1;179(3):489-95. doi: 10.1042/bj1790489.
7
Inhibitory effect of unlabeled iodothyronines on the deiodination of labeled thyroid hormones by cultured hepatocarcinoma cells.未标记的碘甲状腺原氨酸对培养的肝癌细胞标记甲状腺激素脱碘的抑制作用。
Endocrinol Jpn. 1980 Apr;27(2):209-14. doi: 10.1507/endocrj1954.27.209.
8
Reciprocal changes in serum 3, 3', 5'-tri-iodothyronine concentration and the peripheral thyroxine inner ring monodeiodination during food restriction in the young pig.幼猪限食期间血清3,3',5'-三碘甲状腺原氨酸浓度与外周甲状腺素内环单脱碘作用的相互变化
J Endocrinol. 1982 Dec;95(3):349-55. doi: 10.1677/joe.0.0950349.
9
Phenolic and tyrosyl ring deiodination of iodothyronines in rat brain homogenates.大鼠脑匀浆中碘甲状腺原氨酸的酚环和酪氨酰环脱碘作用
J Clin Invest. 1980 Sep;66(3):551-62. doi: 10.1172/JCI109887.
10
Monodeiodination of thyroxine to 3, 5, 3'-triiodothyronine and to 3, 3', 5'-triiodothyronine in isolated dog renal cortical tubuli.在分离的犬肾皮质小管中将甲状腺素单碘化生成3,5,3'-三碘甲状腺原氨酸和3,3',5'-三碘甲状腺原氨酸。
Endocrinol Jpn. 1983 Apr;30(2):211-7. doi: 10.1507/endocrj1954.30.211.
本文引用的文献
1
Determination of total protein in spinal fluid with sulphosalicylic acid and trichloroacetic acid.用磺基水杨酸和三氯乙酸测定脑脊液中的总蛋白
Clin Chim Acta. 1960 Sep;5:757-61. doi: 10.1016/0009-8981(60)90020-6.
2
The metabolism of 3:3':5'-triiodothyronine in man.人血清中3,3',5'-三碘甲状腺原氨酸的代谢
J Clin Endocrinol Metab. 1958 Jul;18(7):713-20. doi: 10.1210/jcem-18-7-713.
3
One-step growth curve of Western equine encephalomyelitis virus on chicken embryo cells grown in vitro and analysis of virus yields from single cells.西部马脑炎病毒在体外培养的鸡胚细胞上的一步生长曲线及单细胞病毒产量分析
J Exp Med. 1954 Feb;99(2):183-99. doi: 10.1084/jem.99.2.183.
4
A radioimmunoassay for measurement of 3,3',5'-triiodothyronine (reverse T3).一种用于测量3,3',5'-三碘甲状腺原氨酸（反式T3）的放射免疫测定法。
J Clin Invest. 1974 Sep;54(3):583-92. doi: 10.1172/JCI107795.
5
Diversion of peripheral thyroxine metabolism from activating to inactivating pathways during complete fasting.完全禁食期间外周甲状腺素代谢从激活途径转向失活途径。
J Clin Endocrinol Metab. 1975 Jul;41(1):191-4. doi: 10.1210/jcem-41-1-191.
6
Circulating 3,3', 5'-triiodothyronine (reverse T3) in the human newborn.人类新生儿体内循环的3,3',5'-三碘甲状腺原氨酸（反式T3）
J Clin Invest. 1975 Jun;55(6):1137-41. doi: 10.1172/JCI108030.
7
Measurement of serum 3,3',5'-(reverse) T3, with comments on its derivation.血清3,3',5' -（反式）三碘甲状腺原氨酸的测定及其来源注释
Clin Endocrinol (Oxf). 1976 Nov;5(6):679-85. doi: 10.1111/j.1365-2265.1976.tb03871.x.
8
An assessment of daily production and significance of thyroidal secretion of 3, 3', 5'-triiodothyronine (reverse T3) in man.人体中3,3',5'-三碘甲状腺原氨酸（反式T3）甲状腺分泌的每日产量及其意义评估。
J Clin Invest. 1976 Jul;58(1):32-40. doi: 10.1172/JCI108456.
9
The failure of physiologic doses of reverse T3 to effect thyroid-pituitary function in man.生理剂量的反三碘甲状腺原氨酸对人体甲状腺-垂体功能无影响。
J Clin Endocrinol Metab. 1976 Aug;43(2):478-81. doi: 10.1210/jcem-43-2-478.
10
L-triiodothyronine and L-reverse-triiodothyronine generation in the human polymorphonuclear leukocyte.人多形核白细胞中L-三碘甲状腺原氨酸和L-反式三碘甲状腺原氨酸的生成
J Clin Invest. 1978 Sep;62(3):577-84. doi: 10.1172/JCI109163.
Zotero 插件