Analgesic and antiinflammatory effects of some new 6-acyl-3-substituted-2(3H)-benzoxazolone derivatives.

6-Acyl-2(3H)-benzoxazolone derivatives were reacted with 4-substituted phenacyl bromide in ethanol to give the corresponding 6-acyl-3-[(4-substitutedbenzoyl)methyl]-2(3H)-benzoxazolones . The compounds were screened for their analgesic, antiinflammatory activities. The eight compounds synthesized showed high analgesic activities and further investigation revealed compounds 3, 6 and 7 to be potent inhibitors of carrageenan- and arachidonic acid-induced paw edema. The PGE2 isolated from the carrageenan paw edema fluid was also significantly low in mice treated with compounds 3, 6 and 7.