Schmidt C A, Oettle H, Ludwig W D, Serke S, Pawlaczyk-Peter B, Wilborn F, Binder L T, Huhn D, Siegert W
Abteilung für Innere Medizin und Poliklinik, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, F.R.G.
Leuk Res. 1994 Jun;18(6):409-13. doi: 10.1016/0145-2126(94)90076-0.
The Raf-1 protein, a cytoplasmic serine/threonine kinase, plays an important role in signal transduction pathways. In order to examine the role of Raf-1 in human myeloid leukemia, we determined raf-1 mRNA expression by Northern blot analysis in blast cell samples from 27 acute myeloid leukemia (AML) cases and peripheral blood mononuclear cells from six healthy donors. A normal raf-1 transcript size was detected in all cases investigated. However, overexpression of raf-1 mRNA was found in 2 of 27 AML cases, both of which were erythroleukemias (AML, FAB M6).
