Mavili M E, Naldoken S, Safak T
Department of Plastic and Reconstructive Surgery, Hacettepe University, Faculty of Medicine, Ankara, Turkey.
Lymphology. 1994 Mar;27(1):14-20.
Radical excision of lymphedematous tissue with skin grafting (Charles operation) may be required for patients with advanced fibrosclerotic lower extremity lymphedema. Complications of this procedure include papillomatosis, wart formation, intractable skin ulcerations and weeping of lymph and are often considered major drawbacks of the operation. We have largely circumvented these sequelae by burying a strip of shaved split-thickness skin graft into the deep subcutaneous tissue thereby modifying the Charles operation. The strip of deepithelialized skin seemingly connects the superficial dermal lymphatics with subfascial deep lymphatics thereby facilitating lymph drainage and minimizing lymphedema accumulation and the complications outlined above. We have now treated 4 patients with advanced primary fibrosclerotic lymphedema using this modified technique. Not only were the patients improved in appearance and function with less trophic changes, but lymphscintigraphy using 99mTc-dextran also suggested improved interstitial tracer transport.
对于晚期纤维硬化性下肢淋巴水肿患者,可能需要进行带皮肤移植的淋巴水肿组织根治性切除(查尔斯手术)。该手术的并发症包括乳头瘤病、疣形成、顽固性皮肤溃疡以及淋巴渗出,这些通常被认为是该手术的主要缺点。我们通过将一条削薄的中厚皮片埋入深皮下组织,从而改进了查尔斯手术,在很大程度上避免了这些后遗症。去上皮化的皮肤条似乎将浅表真皮淋巴管与筋膜下深部淋巴管连接起来,从而促进淋巴引流,减少淋巴水肿积聚以及上述并发症。我们现在已使用这种改良技术治疗了4例晚期原发性纤维硬化性淋巴水肿患者。患者不仅外观和功能得到改善,营养变化减少,而且使用99mTc - 右旋糖酐的淋巴闪烁显像也显示间质示踪剂转运得到改善。