Volenko A V, Germanovich Ch S, Gurova O P, Shvets R A
Med Tekh. 1994 Mar-Apr(2):32-4.
The paper gives data on the composition and strength characteristics and experimental and clinical findings of resolving antimicrobial suture materials, such as Capromed-type one, based on the modified caproic fiber coated by the biocompatible polymer PPB-1 which contains antimicrobial drugs. Capromed threads are demonstrated to have high strength characteristics and resolve in the body within 8-9 months. Coating the modified caproic fibers with the biocompatible copolymer imparts them pseudomonfilament characteristics and prevents the penetration of cellular elements to the thickness of threads. The content of antibacterial agents in the polymer coating confers prolonged antibacterial properties on Capromed. Desorption of antimicrobial agents from Capromed is conducive to more favourable healing, prevents the development of ligature fistulas, favours an over 4-fold reduction in the incidence of wound complications, as compared to the controls.
本文给出了基于含抗菌药物的生物相容性聚合物PPB - 1涂层的改性己内酰胺纤维制成的Capromed型等可降解抗菌缝合材料的成分、强度特性以及实验和临床研究结果。Capromed线具有高强度特性,并在体内8 - 9个月内降解。用生物相容性共聚物涂覆改性己内酰胺纤维赋予其假单丝特性,并防止细胞成分渗透到线的内部。聚合物涂层中抗菌剂的含量赋予Capromed长期抗菌性能。与对照组相比,抗菌剂从Capromed的解吸有利于更良好的愈合,防止结扎瘘的形成,使伤口并发症的发生率降低4倍以上。