Pulici M, Crestan E, Decio B, D'Aloia A, Colombo A M, Picozzi G
Servizio di Anestesia e Rianimazione, Ospedale Fatebenefratelli e Oftalmico, Milano.
Minerva Anestesiol. 1994 Jan-Feb;60(1-2):29-35.
The study evaluates the cardiocirculatory and oxymetric effects of dobutamine infusion in doses between 5 and 15 g/kg/min for a period of 48 hours in 18 critical patients of whom 9 with a low cardiac index (mean 2.1) and 9 with a normal or increased cardiac index (mean 3.3). The beta mimetic effect of the drug is particularly evident in the 9 hypodynamic patients who benefited from a 28% increase in the cardiac index. Likewise, oxygen transport and consumption improved by 22% and 15% respectively. In overall terms, the variables which revealed significant modifications were: cardiac index (CI), systolic index (SI), mean pulmonary pressure (MPAP), pulmonary impaction pressure (PAWP), systemic and pulmonary vascular resistance (SVRO), PVRI), oxygen transport and consumption (DO2, VO2) (No major changes were observed in mean arterial pressure (MAP) and heart rate (HR). No tachyphylaxia was noted after 48 hours of continuous infusion.
该研究评估了在18例危重症患者中，以5至15微克/千克/分钟的剂量静脉输注多巴酚丁胺48小时对心脏循环和血氧指标的影响，其中9例患者心脏指数较低（平均为2.1），9例患者心脏指数正常或升高（平均为3.3）。该药物的β-拟交感神经效应在9例血流动力学不足的患者中尤为明显，这些患者的心脏指数提高了28%。同样，氧运输和氧消耗分别提高了22%和15%。总体而言，显示出显著变化的变量有：心脏指数（CI）、收缩指数（SI）、平均肺动脉压（MPAP）、肺毛细血管楔压（PAWP）、体循环和肺循环血管阻力（SVRO、PVRI）、氧运输和氧消耗（DO2、VO2）（平均动脉压（MAP）和心率（HR）未观察到重大变化。连续输注48小时后未发现快速耐受性。
