Moon Y, Ghoneim M M, Gormezano I
Department of Psychology, University of Iowa, Iowa City 52242.
Pharmacol Biochem Behav. 1994 Mar;47(3):523-9. doi: 10.1016/0091-3057(94)90154-6.
Experiment 1, of a series of six experiments with the rabbit nictitating membrane response (NMR) preparation, revealed that nitrous oxide (0%, 33%, 67%) impaired acquisition of conditioned responses (CRs). Subsequent experiments indicated that nitrous oxide (N2O) had no reliable effects upon nonassociative processes (Experiment 2); impaired unconditioned response (UR) amplitude (Experiment 3); attenuated tone-conditioned stimulus (CS) intensity (Experiment 4); decremented tone-induced reflex modification of the unconditioned NMR (Experiment 5); and demonstrated no reliable evidence of behavioral tolerance (Experiment 6). It was concluded that N2O's impairment of CR acquisition was attributable to its attenuation of the intensity of tone CSs and shock USs and/or UR amplitude. These findings are consistent with the behavioral laws of conditioning: the attenuation of the intensive sensory properties of the CS and US and/or UR components of conditioning affect their ability to enter into the establishment of CS-CR connections and, therefore, the development of associative learning.
在以家兔瞬膜反应（NMR）制备进行的一系列六个实验中的实验1表明，一氧化二氮（0%、33%、67%）会损害条件反应（CR）的习得。随后的实验表明，一氧化二氮（N₂O）对非联想过程没有可靠影响（实验2）；损害无条件反应（UR）幅度（实验3）；减弱音调条件刺激（CS）强度（实验4）；减少音调诱发的无条件NMR的反射改变（实验5）；并且没有显示出行为耐受性的可靠证据（实验6）。得出的结论是，N₂O对CR习得的损害归因于其对音调CS和电击US强度以及/或者UR幅度的减弱。这些发现与条件作用的行为规律一致：CS和US以及/或者条件作用的UR成分的强烈感觉特性的减弱会影响它们建立CS - CR联系的能力，因此也会影响联想学习的发展。
