Evans A E, Poirier O, Kee F, Lecerf L, McCrum E, Falconer T, Crane J, O'Rourke D F, Cambien F
MONICA Project, Dept of Epidemiology and Public Health, UK.
Q J Med. 1994 Apr;87(4):211-4.
It has been shown that myocardial infarction survivors are more likely to carry an insertion/deletion polymorphism (I/D) of the angiotensin-converting-enzyme (ACE) gene than age-matched population controls. To test whether the association with coronary risk had been under-estimated, the frequency of the ACE I/D was studied in 213 fatal cases of definite and possible myocardial infarction which came to autopsy in the Belfast MONICA Project area. In comparison to controls from the same population, the autopsy cases had an increased frequency of the ACE D allele (p < 0.02). The overall odds ratios were 2.2 for DD vs. II, and 1.8 for ID vs II (test for trend p = 0.01). The findings bear out the hypothesis that the ACE I/D polymorphism is a risk factor for fatal myocardial infarction and sudden cardiac death.
研究表明，与年龄匹配的人群对照组相比，心肌梗死幸存者更有可能携带血管紧张素转换酶（ACE）基因的插入/缺失多态性（I/D）。为了检验与冠心病风险的关联是否被低估，在贝尔法斯特莫尼卡项目区域对213例经尸检确诊为明确或可能心肌梗死的死亡病例进行了ACE I/D频率研究。与来自同一人群的对照组相比，尸检病例中ACE D等位基因的频率增加（p < 0.02）。DD与II相比的总体优势比为2.2，ID与II相比为1.8（趋势检验p = 0.01）。这些发现证实了ACE I/D多态性是致命性心肌梗死和心源性猝死危险因素的假设。
