Kuczyński W I, Ratajczak M Z
Department of Immunology CSK WAM, Warsaw.
Acta Haematol Pol. 1994;25(1):43-6.
The aim of this study was to evaluate the presence of the mRNA for the hematopoietic STK-1 receptor in various human tumor cell lines using RT-PCR directed analysis of gene expression. We have found STK-1R mRNA to be expressed in non-hematopoietic malignant cells of ectodermal, endodermal and mesodermal origin confirms a hypothesis that STK-1R is similar to other receptors with intrinsic tyrosine kinase activity, is not for specific hematopoiesis and is also expressed in non-hematopoietic cells. The fact that STK-1R is detectable in different tumor cell lines should also inspire further studies to evaluate its role in the transformation and growth of malignant cells.
本研究的目的是通过逆转录聚合酶链反应（RT-PCR）对基因表达进行定向分析，评估造血STK-1受体的mRNA在各种人类肿瘤细胞系中的存在情况。我们发现STK-1R mRNA在外胚层、内胚层和中胚层来源的非造血恶性细胞中表达，这证实了一个假设，即STK-1R与其他具有内在酪氨酸激酶活性的受体相似，并非特异性参与造血过程，也在非造血细胞中表达。STK-1R在不同肿瘤细胞系中可被检测到这一事实，也应促使进一步研究以评估其在恶性细胞转化和生长中的作用。
