van Buul P P
Mutat Res. 1976 Aug;36(2):223-36. doi: 10.1016/0027-5107(76)90009-9.
Frequencies of radiation-induced chromosome aberrations in spermatogonia, peripheral blood lymphocytes and bone-marrow cells of the rhesus monkey (Macaca mulatta) and in human blood lymphocytes, were determined at different exposures of X-rays. The dose-response curve for the induction of reciprocal translocations in spermatogonia suggested a "hump" at about 200 rad. The absolute frequencies of chromosome aberrations in somatic and germ cells of the rhesus monkey were low in comparison with most other mammalian species and the ratio between aberrations in the two tissues was 25 to 1 at the 100 rad level. Although the numbers of "effective chromosome arms" in man and rhesus monkeys are similar (81 vs. 83), the rhesus monkey showed a lower rate of induction of dicentrics in blood lymphocytes than man at all doses, reaching statistical significance at the 300 rad level.
在不同X射线照射剂量下，测定了恒河猴（猕猴属）精原细胞、外周血淋巴细胞和骨髓细胞以及人类血淋巴细胞中辐射诱导的染色体畸变频率。精原细胞中相互易位诱导的剂量反应曲线表明，在约200拉德处出现一个“峰值”。与大多数其他哺乳动物物种相比，恒河猴体细胞和生殖细胞中染色体畸变的绝对频率较低，在100拉德水平时，这两种组织中畸变的比例为25比1。尽管人类和恒河猴的“有效染色体臂”数量相似（分别为81条和83条），但在所有剂量下，恒河猴血淋巴细胞中双着丝粒的诱导率均低于人类，在300拉德水平时达到统计学显著差异。
