Acosta P B
Ross Products Division, Abbott Laboratories, Columbus, Ohio 43215.
Am J Med Genet. 1994 May 1;50(4):358-63. doi: 10.1002/ajmg.1320500412.
A high cholesterol diet has been suggested to help prevent the poor reproductive outcomes found in heterozygote carriers of fetuses affected with the Smith-Lemli-Opitz (SLO) syndrome. The theory has also been presented that a high cholesterol medical food may enhance myelination of the central nervous system of the infant and prevent demyelination in the child and adult with SLO. Clinical studies are required to test this hypothesis and to determine the optimal composition of such medical foods. FDA requires proof of efficacy and controls nutrient composition, ingredients, and label claims of medical foods.
有人提出，高胆固醇饮食有助于预防患有史密斯-利姆利-奥皮茨（SLO）综合征胎儿的杂合子携带者出现不良生殖结局。还有理论认为，高胆固醇医用食品可能会增强婴儿中枢神经系统的髓鞘形成，并预防患有SLO的儿童和成人出现脱髓鞘。需要进行临床研究来验证这一假设，并确定此类医用食品的最佳成分。美国食品药品监督管理局要求证明医用食品的功效，并对其营养成分、成分和标签声明进行管控。
