Binder J R, Rao S M, Hammeke T A, Yetkin F Z, Jesmanowicz A, Bandettini P A, Wong E C, Estkowski L D, Goldstein M D, Haughton V M
Department of Neurology, Medical College of Wisconsin, Milwaukee 53226.
Ann Neurol. 1994 Jun;35(6):662-72. doi: 10.1002/ana.410350606.
Magnetic resonance imaging methods recently demonstrated regional cerebral signal changes in response to limb movement and visual stimulation, attributed to blood flow enhancement. We studied 5 normal subjects scanned while listening to auditory stimuli including nonspeech noise, meaningless speech sounds, single words, and narrative text. Imaged regions included the lateral aspects of both hemispheres. Signal changes in the superior temporal gyrus and superior temporal sulcus were observed bilaterally in all subjects. Speech stimuli were associated with significantly more widespread signal changes than was the noise stimulus, while no consistent differences were observed between responses to different speech stimuli. Considerable intersubject variability in the topography of signal changes was observed. These observations confirm the utility of magnetic resonance imaging in the study of human brain structure-function relationships and emphasize the role of the superior temporal gyrus in perception of acoustic-phonetic features of speech, rather than processing of semantic features.
磁共振成像方法最近证实，由于血流增强，大脑局部区域会对肢体运动和视觉刺激产生信号变化。我们对5名正常受试者进行了扫描，扫描时他们聆听包括非语音噪声、无意义语音、单个单词和叙述文本在内的听觉刺激。成像区域包括双侧大脑半球的外侧。所有受试者双侧颞上回和颞上沟均观察到信号变化。与噪声刺激相比，语音刺激引发的信号变化分布范围明显更广，而对不同语音刺激的反应之间未观察到一致的差异。观察到受试者之间信号变化的地形图存在相当大的变异性。这些观察结果证实了磁共振成像在研究人类脑结构-功能关系中的实用性，并强调了颞上回在语音声学-语音特征感知而非语义特征处理中的作用。
