Uchida J, Satake H, Saito H, Nakano K, Takeda S, Unemi N
Anticancer and Antimicrobials Research Laboratory, Taiho Pharmaceutical Co., Ltd.
Gan To Kagaku Ryoho. 1994 Jun;21(7):1001-8.
Combined treatment of UFT with cisplatin (CDDP) achieved remarkable elongation of survival time of BDF1 mice, which were intravenously transplanted with Lewis lung carcinoma (LLC). Three cycles of weekly iv administration of CDDP and vindesine (VDS), and daily oral administration of UFT were scheduled. Combination UFT (18 mg/kg/day) with CDDP (6.0 mg/kg/day) yielded tumor-free survivors in all of the treated animals with slight body weight loss. Its efficacy was superior to that of the combination of CDDP with VDS. Supra-additive cytotoxic activity against LLC cells was observed by Isobologram method on the schedule of the exposure to 5-fluorouracil preceding the exposure to CDDP. Additive effect was observed by the reversed schedule of the treatment. Using human non-small-cell lung cancer (NSCLC) cell lines which derived from histologically different type, additive or greater additive sensitivity to both of the sequential treatment schedules with 5-FU and CDDP was observed. These results suggest that the combination chemotherapy of UFT with CDDP for lung cancer may show high antitumor efficacy with low toxicity in a clinical setting.
对静脉移植Lewis肺癌（LLC）的BDF1小鼠，优福定（UFT）与顺铂（CDDP）联合治疗显著延长了其生存时间。制定了每周静脉注射CDDP和长春地辛（VDS）共三个周期，同时每日口服UFT的治疗方案。UFT（18毫克/千克/天）与CDDP（6.0毫克/千克/天）联合使用，使所有接受治疗的动物都出现了无瘤存活，体重略有减轻。其疗效优于CDDP与VDS的联合使用。通过等高线图法观察到，在CDDP暴露前先暴露于5-氟尿嘧啶的方案中，对LLC细胞具有超相加细胞毒性活性。在相反的治疗方案中观察到相加效应。使用源自不同组织学类型的人非小细胞肺癌（NSCLC）细胞系，观察到对5-氟尿嘧啶和CDDP的两种序贯治疗方案均具有相加或更高的相加敏感性。这些结果表明，UFT与CDDP联合化疗在临床环境中对肺癌可能显示出高抗肿瘤疗效和低毒性。
