Gordon P B, Goldenberg S L, Chan N H
Department of Radiology, University of British Columbia, Vancouver, Canada.
Radiology. 1993 Nov;189(2):573-80. doi: 10.1148/radiology.189.2.8210392.
To ascertain the usefulness of real-time ultrasound (US)-guided fine-needle aspiration biopsy as an adjunct to clinical, mammographic, and sonographic assessment of solid breast lesions.
US-guided fine-needle aspiration biopsy was performed in 225 malignant and 580 benign solid breast lesions confirmed by means of excisional biopsy or with imaging follow-up (mammography or US) performed at approximate intervals of 6, 12, 24, and 36 months. All lesions were classified as palpable or nonpalpable at clinical examination and visible or nonvisible on mammograms.
In 213 malignant lesions (95%), the cytologic findings were malignant or suspicious, with no false-positive and 12 false-negative cases. Mammography did not enable detection of 58 cancers (26%), 43 of which were palpable. Fifteen cancers discovered with US were nonpalpable and not seen on mammograms. Cytologic diagnosis of fibroadenoma or nonspecific benign cells was correct in 535 lesions. The sensitivity of this method was 95%; specificity, 92%; and overall accuracy, 93%.
Real-time US-guided fine-needle aspiration biopsy is a useful adjunct to clinical, mammographic, and sonographic assessment of solid breast lesions.
确定实时超声（US）引导下细针穿刺活检作为乳腺实性病变临床、乳腺X线摄影及超声评估辅助手段的实用性。
对225例经切除活检证实或经约6、12、24和36个月的影像学随访（乳腺X线摄影或超声）证实的恶性乳腺实性病变以及580例良性乳腺实性病变进行了US引导下细针穿刺活检。所有病变在临床检查时分为可触及或不可触及，在乳腺X线片上分为可见或不可见。
在213例恶性病变（95%）中，细胞学检查结果为恶性或可疑，无假阳性病例，有12例假阴性病例。乳腺X线摄影未能检测出58例癌症（26%），其中43例为可触及的。超声发现的15例癌症不可触及且在乳腺X线片上未见。535例病变的纤维腺瘤或非特异性良性细胞的细胞学诊断正确。该方法的敏感性为95%；特异性为92%；总体准确率为93%。
实时US引导下细针穿刺活检是乳腺实性病变临床、乳腺X线摄影及超声评估的有用辅助手段。
