癸酸诺龙可降低心肌病仓鼠的过早死亡率。

Nandrolone decanoate reduces the premature mortality of cardiomyopathic hamsters.

作者信息

Davis W M, Long S F, Lin T L

机构信息

Department of Pharmacology, University of Mississippi, University 38677.

出版信息

Res Commun Chem Pathol Pharmacol. 1993 Jul;81(1):21-32.

PMID:8210687

Abstract

Male hamsters of an inbred strain carrying a genetic trait for cardiomyopathy were dosed by sc injection weekly with an anabolic-androgenic steroid, nandrolone decanoate, beginning when 3 months old. Two groups (N = 17) received doses of 2 and 4 mg per animal, while a vehicle control group received an equal volume of sesame oil. Rather than a hypothesized shortening of longevity, the steroid treatment significantly prolonged survival of the hamsters, which ordinarily die of congestive heart failure. At the median time to death for controls (355 days of age, 257 days of treatment), the steroid groups had mortality of only 2/17 and 4/17 (vs. 9/17, p < 0.01).

摘要

携带心肌病遗传特征的近交系雄性仓鼠，从3个月大开始，每周皮下注射一次合成代谢雄激素类固醇癸酸诺龙。两组（每组n = 17）每只动物分别接受2毫克和4毫克的剂量，而一个溶媒对照组接受等量的芝麻油。类固醇治疗并未如预期那样缩短寿命，反而显著延长了仓鼠的存活时间，这些仓鼠通常死于充血性心力衰竭。在对照组的中位死亡时间（355日龄，257天的治疗时间），类固醇组的死亡率仅为2/17和4/17（相比之下，对照组为9/17，p < 0.01）。