Kisara S, Maekawa I, Sasaki K, Suzuki N, Hayashi A, Furusawa S, Takayanagi Y, Sasaki K
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
Res Commun Chem Pathol Pharmacol. 1993 Aug;81(2):247-50.
The antitumor activity of acemetacin (ACM) was examined in mice bearing colon 26 carcinoma and its effect was compared with indomethacin (IND). The addition of ACM (0.001-0.003%) to drinking water prolonged the survival time of mice bearing colon 26. On the other hand, prostaglandin E2 (PGE2) reduced the effect of ACM. The results suggest that the antitumor activity of ACM may be associated with the reduction of PGE2 levels.
在携带结肠26癌的小鼠中检测了阿西美辛（ACM）的抗肿瘤活性，并将其效果与吲哚美辛（IND）进行比较。在饮用水中添加ACM（0.001 - 0.003%）可延长携带结肠26癌小鼠的存活时间。另一方面，前列腺素E2（PGE2）降低了ACM的效果。结果表明，ACM的抗肿瘤活性可能与PGE2水平的降低有关。
