Sharp E
Williamson Medical Center, Franklin, TN.
Semin Oncol Nurs. 1993 Aug;9(3 Suppl 1):14-9.
Patients receiving intermediate-dose CI rIL-2 therapy require hospitalization for assessment and management of the potentially severe side effects, primarily those involved with cardiopulmonary and renal toxicities. Once the tolerable dose level has been identified for a particular patient, the severity of the side effects on subsequent cycles of therapy may decrease. During therapy, nursing management includes interventions to minimize distressing side effects such as fever, flu-like symptoms, fatigue, anorexia, and pruritus. Because the side effects of rIL-2 therapy are predictable, nurses can focus on early detection of these side effects and institute prompt interventions to reduce, minimize, or eliminate the symptoms. As oncology nurses prepare to care for hospitalized patients receiving rIL-2, a knowledge of the agent's side effect profile provides the foundation on which to base nursing practice.
接受中等剂量环磷酰胺重组白细胞介素-2（CI rIL-2）治疗的患者需要住院，以便对可能出现的严重副作用进行评估和处理，主要是那些与心肺和肾脏毒性相关的副作用。一旦确定了特定患者的耐受剂量水平，后续治疗周期中副作用的严重程度可能会降低。在治疗期间，护理管理包括采取干预措施，尽量减少令人痛苦的副作用，如发热、流感样症状、疲劳、厌食和瘙痒。由于rIL-2治疗的副作用是可预测的，护士可以专注于这些副作用的早期检测，并及时采取干预措施以减轻、最小化或消除症状。当肿瘤专科护士准备护理接受rIL-2治疗的住院患者时，了解该药物的副作用情况为护理实践提供了基础。
