Ranek L, Dalhoff K, Poulsen H E, Brøsen K, Flachs H, Loft S, Wantzin P
Dept. of Internal Medicine A, Rigshospitalet, Copenhagen, Denmark.
Scand J Gastroenterol. 1993 Aug;28(8):677-80. doi: 10.3109/00365529309098271.
To test the hypothesis that halothane hepatitis is caused by a combination of altered drug metabolism and an immunoallergic disposition, the metabolism of antipyrine, metronidazole, sparteine, phenytoin, and racemic R- and S-mephenytoin was investigated in seven subjects with previous halothane hepatitis. The HLA tissue types and the complement C3 phenotypes were also determined. The metabolism of antipyrine and metronidazole was within normal range in all subjects, and they were all fast or extensive metabolizers of sparteine, mephenytoin, and phenytoin. HLA tissue types were unremarkable. Five of the seven subjects had complement C3 phenotypes F or FS. In the general population phenotype S is the most common, but the difference in complement C3 phenotypes is not statistically significant (p = 0.07). We conclude, although in a limited number of patients, that subjects with previous halothane hepatitis do not appear to be different from controls with regard to drug metabolism and HLA tissue type. The possibility of a higher frequency of complement C3 phenotype F and FS needs further investigation.
为了验证氟烷性肝炎是由药物代谢改变和免疫过敏倾向共同引起这一假说，我们对7名曾患氟烷性肝炎的受试者进行了安替比林、甲硝唑、司巴丁、苯妥英以及消旋R-和S-美芬妥英的代谢研究。同时还测定了他们的HLA组织类型和补体C3表型。所有受试者的安替比林和甲硝唑代谢均在正常范围内，并且他们都是司巴丁、美芬妥英和苯妥英的快速或广泛代谢者。HLA组织类型无异常。7名受试者中有5名具有补体C3表型F或FS。在普通人群中，表型S最为常见，但补体C3表型的差异无统计学意义（p = 0.07）。我们得出结论，尽管患者数量有限，但曾患氟烷性肝炎的受试者在药物代谢和HLA组织类型方面似乎与对照组并无差异。补体C3表型F和FS出现频率较高的可能性需要进一步研究。
