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[衰老大鼠脑内血管丛不同ATP酶和碱性磷酸酶的超微细胞化学研究]

[Ultracytochemical research on the different ATPases and alkaline phosphatase of the vascular plexuses of the rat brain in aging].

作者信息

Kvitnitskaia-Ryzhova T Iu

出版信息

Tsitol Genet. 1993 Mar-Apr;27(2):37-41.

PMID:8212324
Abstract

The ultracytochemical investigation of the localization of Mg(2+)-ATPase, Na+, K(+)-ATPase (ouabain-sensitive potassium-dependent p-nitrophenylphosphatase component of Na+, K(+)-ATPase complex), Ca(2+)-ATPase and alkaline phosphatase activities in choroid plexus of the adult and old rat brain ventricles has shown the age-related decrease in intensity of the enzymatic reactions. This can influence the character of liquor production, as well as metabolic, regulatory and transport processes in the blood-liquor barrier in aging. The most typical areas of enzymes activity localization have been established, which are zones of the greatest functional significance.

摘要

对成年和老年大鼠脑室脉络丛中Mg(2+)-ATP酶、Na+,K(+)-ATP酶(Na+,K(+)-ATP酶复合物中对哇巴因敏感的钾依赖性对硝基苯磷酸酶成分)、Ca(2+)-ATP酶和碱性磷酸酶活性定位的超微细胞化学研究表明,酶反应强度随年龄增长而降低。这可能会影响脑脊液生成的特性,以及衰老过程中血-脑脊液屏障的代谢、调节和转运过程。已经确定了酶活性定位最典型的区域,这些区域具有最大的功能意义。

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