Peleg B A, Samina I, Brenner J
State Laboratory for Vaccine Control, Kimron Veterinary Institute, Bet Dagan, Israel.
Vaccine. 1993;11(10):1074-6. doi: 10.1016/0264-410x(93)90136-l.
Chickens of various ages and breeds were vaccinated subcutaneously with Newcastle disease live-in-oil vaccines. These vaccines were prepared immediately prior to the vaccination by mixing the lyophilized live vaccine with the oil adjuvant, which was kept at room temperature. The live-in-oil vaccines were shown to be 30-50 times more effective in efficacy tests than either the same vaccines reconstituted in water or killed-in-oil vaccines. In addition to its biological advantage, the method of preparation of live-in-oil vaccine saves the expensive space of cold storage and shipment necessary for conventional killed-in-oil vaccines.
给不同年龄和品种的鸡皮下接种新城疫油包活疫苗。这些疫苗在接种前立即通过将冻干活疫苗与保存在室温下的油佐剂混合制备而成。在效力测试中，油包活疫苗的效力比在水中重构的相同疫苗或油包死疫苗高30至50倍。除了具有生物学优势外，油包活疫苗的制备方法还节省了传统油包死疫苗所需的昂贵冷藏和运输空间。
