Furuhata M, Fujimoto Y, Nukui F, Nagata M, Okamoto S, Kumasaka T, Saiki S, Sata T
Department of Urology, St. Luke's International Hospital.
Hinyokika Kiyo. 1993 Sep;39(9):857-61.
We report a case of urethral condyloma acuminatum with severe dysplasia detected human papillomavirus (HPV) type 11. A 47-year-old male patient visited St. Luke's International Hospital complaining of tumor at the urethral meatus. One small papillary lesion was found and excised. Histopathological examination revealed condyloma acuminatum with severe dysplasia. Immunohistochemical detection for HPV antigen in the specimen of condyloma acuminatum was positive and that of severe dysplasia was negative. In an electron microscopical study, viral particles were demonstrated only in the specimen of condyloma acuminatum. Detection of HPV DNA was performed using in situ hybridization (ISH) and southern blot hybridization (SBH). HPV type 11 was found in both lesions. In conclusion, although previous studies have shown that HPV type 16/18 was especially correlated with genital severe dysplasia and carcinoma, the process of malignant transformation was suggested in the association with HPV type 11.
我们报告一例尿道尖锐湿疣伴严重发育异常病例，检测出11型人乳头瘤病毒（HPV）。一名47岁男性患者因尿道口肿物就诊于圣路加国际医院。发现一个小的乳头状病变并将其切除。组织病理学检查显示为伴有严重发育异常的尖锐湿疣。尖锐湿疣标本中HPV抗原的免疫组化检测呈阳性，而严重发育异常标本的检测呈阴性。在电子显微镜研究中，仅在尖锐湿疣标本中发现病毒颗粒。使用原位杂交（ISH）和Southern印迹杂交（SBH）进行HPV DNA检测。在两个病变中均发现11型HPV。总之，尽管先前的研究表明16/18型HPV与生殖器严重发育异常和癌特别相关，但提示11型HPV也参与了恶性转化过程。
