Kohan D E
Department of Medicine, Veterans Affairs Medical Center, Salt Lake City, UT.
Am J Kidney Dis. 1993 Oct;22(4):493-510. doi: 10.1016/s0272-6386(12)80920-6.
In summary, ET may be important in the pathogenesis of multiple diseases of the kidney. Alterations in ET-1 production and action may lead to severe vasoconstriction, mesangial cell contraction, glomerular cell proliferation, and enhanced sodium and water retention. It is not surprising, therefore, that intense investigations are under way in an effort to develop specific inhibitors of ET action, including ECE inhibitors and ET receptor blockers. It is likely that with the development of these agents, we will uncover even more diseases in which ET mediates renal dysfunction and in which, hopefully, blockers of ET action will be of therapeutic benefit.
总之，内皮素（ET）可能在多种肾脏疾病的发病机制中起重要作用。ET-1产生和作用的改变可能导致严重的血管收缩、系膜细胞收缩、肾小球细胞增殖以及钠和水潴留增强。因此，正在进行深入研究以开发ET作用的特异性抑制剂，包括内皮素转换酶（ECE）抑制剂和ET受体阻滞剂，这并不奇怪。随着这些药物的开发，我们很可能会发现更多由ET介导肾功能障碍的疾病，并且有望发现ET作用阻滞剂具有治疗益处。
