Grundy D, Gharib-Naseri M K, Hutson D
Department of Biomedical Science, University of Sheffield, United Kingdom.
Am J Physiol. 1993 Sep;265(3 Pt 1):G432-9. doi: 10.1152/ajpgi.1993.265.3.G432.
Changes in gastric corpus tone have been characterized during two procedures that compromise the major inhibitory innervation of the stomach: immunoneutralization of endogenous vasoactive intestinal polypeptide (VIP) and chronic vagotomy. After both procedures, there was a small but significant increase in intracorpus pressure generated during ramp increases in volume compared with sham immunized controls but not when the procedures were combined in vagotomized immunized animals. Adaptation in the mechanisms controlling corpus tone was most apparent after atropine (100 micrograms/kg) and acute vagal section when tone was low in sham immunized vagotomized and vagotomized immunized animals (4.4 +/- 0.3 and 3.7 +/- 0.8 cmH2O, respectively) and high in immunized and sham immunized animals (6.5 +/- 0.4 and 6.2 +/- 0.5 cmH2O) despite a similar sensitivity to atropine. Corpus responses to low-frequency vagal stimulation were maintained in immunized animals despite the absence of a response to exogenous VIP. We conclude that gastric reservoir function adapts to the loss of the vagal inhibitory innervation by an upregulation of intrinsic reflex pathways controlling myenteric inhibitory neurons, which are non-VIPergic.
在两种破坏胃主要抑制性神经支配的操作过程中，已对胃体张力的变化进行了表征：内源性血管活性肠肽（VIP）的免疫中和以及慢性迷走神经切断术。与假免疫对照组相比，在这两种操作后，随着体积呈斜坡式增加所产生的胃内压均有小幅但显著的升高，但在迷走神经切断术免疫动物中将这两种操作联合进行时则不然。当假免疫迷走神经切断术和迷走神经切断术免疫动物的张力较低（分别为4.4±0.3和3.7±0.8 cmH₂O），而免疫动物和假免疫动物的张力较高（分别为6.5±0.4和6.2±0.5 cmH₂O）时，尽管对阿托品的敏感性相似，但在给予阿托品（100微克/千克）和急性迷走神经切断后，控制胃体张力的机制中的适应性最为明显。尽管对外源性VIP无反应，但免疫动物中胃体对低频迷走神经刺激的反应得以维持。我们得出结论，胃储存功能通过上调控制肌间抑制性神经元的内在反射途径来适应迷走神经抑制性神经支配的丧失，这些肌间抑制性神经元是非VIP能的。
