Itti R, Morand P, Planiol T, Pellois A, Marchal C
Arch Mal Coeur Vaiss. 1976 Jun;69(6):565-72.
Red blood cells labelled with radioactive Technetium were injected intravenously, and the passage of the tracer through the cardio-pulmonary system recorded using a scintillation camera coupled with a numerical dosimeter. The results are presented as serial analoque pictures taken at the rate of two per second, as numerical tracings which are later processed, and as flow charts from predetermined areas of interest: the chambers of the heart, the lung parenchyma, and the aorta. This study is concerned with 58 patients with a left-to-right shunt, and about 40 normal examinations were used as a baseline for comparison. In cases of left-to-right shunt, the finding on the tracings is of abnormally prolonged activity in the lungs after a normal passage through the right side. The intensity-duration curves highlight this finding, and show an early recirculation peak in the right side of the heart and a slowing of pulmonary emptying, which can be evaluated numerically from the ratio C2/C1. A correlation has been found between this value and the ratio of pulmonary to systemic flow as calculated by oximetry. The correlation is even closer if a comparison is made between the curves of pulmonary radioactivity and the dye dilution curves. In certain cases, the shunt can be localised to the atrial or ventricular level. There are many indications for this safe investigation: --the diagnosis and monitoring of the flow through a left-to-right shunt in a child; --confirmation of the closure of septal defects after surgery; --clarification of an infudibulo-pulmonary syndrome.
将标记有放射性锝的红细胞静脉注射,然后使用与数字剂量计相连的闪烁相机记录示踪剂通过心肺系统的过程。结果以每秒两张的速率拍摄的系列模拟图片、后续处理的数字描记图以及来自预定感兴趣区域(心脏腔室、肺实质和主动脉)的流程图呈现。本研究涉及58例左向右分流患者,并以约40例正常检查作为比较基线。在左向右分流的病例中,描记图上的发现是在正常通过右侧后肺部活动异常延长。强度 - 持续时间曲线突出了这一发现,并显示出心脏右侧的早期再循环峰值和肺排空减慢,这可以通过C2/C1比值进行数值评估。已发现该值与通过血氧测定法计算的肺循环与体循环血流量比值之间存在相关性。如果比较肺放射性曲线和染料稀释曲线,相关性会更紧密。在某些情况下,分流可定位在心房或心室水平。这项安全检查有许多适应证:——诊断和监测儿童左向右分流的血流;——确认手术后室间隔缺损的闭合;——明确漏斗 - 肺综合征。