Steffen C
Am J Dermatopathol. 1993 Aug;15(4):306-10.
Four cases of neoplasms with mantle differentiation are presented. The mantle (sebaceous mantle) is a well-described but little known part of the sebaceous gland cycle. In the resting phase of that cycle, the mantle is seen as cords of undifferentiated cells that emanate from the infundibulum of a hair follicle and droop down aside the follicle in the form of a mantle or skirt. Cyclically, vacuolated sebocytes appear at the terminus of these cords, singly, then in groups, and finally as fully developed sebaceous lobules and glands. Presumably, sebaceous glands involute to become undifferentiated mantles. Clinically, neoplasms with mantle distribution occur on the face. Three of our cases were found fortuitously in sections of tissue removed because of basal-cell carcinoma. One was thought by the clinician to be a basal-cell carcinoma. Histopathologically, mantleomas vary in complexity. Presumably early neoplasms consist only of cords and columns of undifferentiated epithelial cells that radiate from an infundibulum. Later on, these cords interweave in a retiform pattern that contains sebocytes of varying degrees of vacuolization and sebaceous ductal structures. Mantleomas are benign because none in our series recurred after surgical removal and no atypical neoplastic cells were seen histopathologically.
本文报告了4例具有皮脂腺膜分化的肿瘤。皮脂腺膜（皮脂膜）是皮脂腺周期中一个描述详尽但鲜为人知的部分。在该周期的静止期，皮脂腺膜表现为从毛囊漏斗部发出的未分化细胞索，呈膜状或裙状垂落在毛囊旁。周期性地，空泡化的皮脂腺细胞出现在这些细胞索的末端，先是单个出现，然后成组出现，最终形成完全成熟的皮脂腺小叶和腺体。据推测，皮脂腺会退化成为未分化的皮脂膜。临床上，具有皮脂膜分布的肿瘤发生于面部。我们的3例病例是在因基底细胞癌切除的组织切片中偶然发现的。有1例被临床医生认为是基底细胞癌。组织病理学上，皮脂腺膜瘤的复杂程度各不相同。据推测，早期肿瘤仅由从漏斗部放射状排列的未分化上皮细胞索和柱状结构组成。后来，这些细胞索以网状模式交织，其中包含不同程度空泡化的皮脂腺细胞和皮脂腺导管结构。皮脂腺膜瘤是良性的，因为我们系列中的病例在手术切除后均未复发，且组织病理学上未见非典型肿瘤细胞。
