[Distribution, absorption and elimination of radioactivity following oral and intravenous application of 2'-14C-labelled cyproterone acetate to rhesus monkeys (author's transl)].

13 female rhesus monkeys were given 2'-14C-cyproterone acetate i.v. and p.o. The radioactivity of the blood plasma and the elimination in urine and faeces were then measured at suitable intervals for a period of 12 days. After i.v. administration the time for distribution in the body amounted to 8 h. The extrapolated initial concentrations in the equilibrium to distribution amounted to 0.68% of the administered dose in the plasma volume, and the theoretical volume of distribution was 5 times the body volume. After oral administration the maximum levels in the plasma were reached on an average 13 h after administration. They attained the level of the extrapolated initial concentration after i.v. administration. The compound was eliminated from the body with a radioactive half-life of 1.6 to 1.8 days, irrespective of the route of administration. The mean ratio of elimination urine: faeces was approximately 0.7 for all animals. After oral administration 81% of the dose was absorbed on the average.