McGrath B J, Marchbanks C R, Gilbert D, Dudley M N
Antiinfective Pharmacology Research Unit, University of Rhode Island College of Pharmacy, Roger Williams Medical Center, Providence 02908.
Antimicrob Agents Chemother. 1993 Aug;37(8):1723-5. doi: 10.1128/AAC.37.8.1723.
The postantibiotic effect (PAE) following three consecutive 2-h exposures to imipenem, temafloxacin, and tobramycin was determined in Pseudomonas aeruginosa. A PAE and a bactericidal effect were consistently observed for imipenem following each cycle of drug exposure and regrowth. In contrast, the PAE increased with repeated exposure with temafloxacin (1.8 to > 5 h), but disappeared with tobramycin by the third exposure (0.9 to 0 h). These data show that the in vitro PAE may change within a strain following multiple cycles of drug exposure and bacterial regrowth.
在铜绿假单胞菌中测定了连续3次2小时暴露于亚胺培南、替马沙星和妥布霉素后的抗生素后效应（PAE）。在每次药物暴露和再生长循环后，亚胺培南均持续观察到PAE和杀菌作用。相比之下，替马沙星重复暴露后PAE增加（1.8至>5小时），但妥布霉素第三次暴露时PAE消失（0.9至0小时）。这些数据表明，在多次药物暴露和细菌再生长循环后，同一菌株内的体外PAE可能会发生变化。
