Shinohara N
Dept. of Orthopedic Surgery, National Fukuoka Central Hospital.
Gan To Kagaku Ryoho. 1993 Oct;20(13):1923-9.
The literatures concerning intra-arterial versus intra-venous infusion as a preoperative chemotherapy for bone and soft tissue sarcomas were reviewed in this paper. The initial purpose of the therapies are to give the surgeons useful and helpful preparation for limb salvage surgery. Otherwise, they are also useful to evaluate the efficacy of the chemotherapeutic agents. However, it takes a few months for the therapy to be able to evaluate the response to the tumors and the therapy do not always have good response, therefore, it is important to pay a great care in performing the therapy. From the literatures, it is difficult to clarify the differences of each methods because of the variable histological results. Some authors report the higher local concentration of the agents in intra-arterial infusion. Arterial infusion have to be indicated as a locally useful method with a attention to systemic therapy.
本文回顾了有关动脉内输注与静脉内输注作为骨肉瘤和软组织肉瘤术前化疗的文献。这些治疗的最初目的是为保肢手术的外科医生提供有用且有帮助的准备。此外，它们对于评估化疗药物的疗效也很有用。然而，该治疗需要几个月时间才能评估对肿瘤的反应，而且该治疗并不总是有良好的反应，因此，在进行治疗时要格外小心。从文献来看，由于组织学结果多变，很难阐明每种方法的差异。一些作者报告动脉内输注时药物的局部浓度更高。动脉内输注必须作为一种局部有用的方法加以应用，同时要注意全身治疗。
