Jeffrey P B, Davis R L, Biava C, Rosenblum M
Department of Pathology, University of California, San Francisco.
Arch Pathol Lab Med. 1993 Oct;117(10):1055-7.
We report a case of a clival chordoma in a 21-year-old man that ultrastructurally demonstrated large numbers of microtubule aggregates within the rough endoplasmic reticulum. Histologically, the tumor demonstrated classic chordoma architecture characterized by numerous physaliphorous cells and an abundant extracellular matrix. The tumor cells stained strongly for cytokeratin, S100 protein, and epithelial membrane antigen, indicative of the epithelial origin of this tumor. Ultrastructurally, the most conspicuous feature of this tumor consisted of parallel bundles of criss-crossing microtubules within the rough endoplasmic reticulum. These microtubules had a diameter of approximately 27 nm and did not demonstrate an internal structure. To our knowledge, this is the first report of microtubule aggregates in a spheno-occipital chordoma. We note that microtubule aggregates have been described in a number of different entities, and though proposed as a specific feature of "chondroid chordoma," they are a nonspecific finding.
我们报告一例21岁男性的斜坡脊索瘤，超微结构显示粗面内质网内有大量微管聚集体。组织学上，肿瘤呈现典型的脊索瘤结构，其特征为大量泡状细胞和丰富的细胞外基质。肿瘤细胞细胞角蛋白、S100蛋白和上皮膜抗原染色强阳性，提示该肿瘤起源于上皮。超微结构上，该肿瘤最显著的特征是粗面内质网内有平行排列、相互交叉的微管束。这些微管直径约27nm，无内部结构。据我们所知，这是蝶枕部脊索瘤中微管聚集体的首次报道。我们注意到微管聚集体已在多种不同病变中被描述，尽管被认为是“软骨样脊索瘤”的特异性特征，但它们是一种非特异性表现。
