Wengs W J, Talwar D, Bernard J
Department of Neurology, University of Minnesota, Minneapolis.
Arch Neurol. 1993 Oct;50(10):1104-5. doi: 10.1001/archneur.1993.00540100089024.
We report the first case of nonconvulsive status epilepticus as a complication of chemotherapy with the nitrogen mustard derivative ifosfamide. Our patient developed encephalopathy, upper extremity myoclonus, and a periodic, triphasic electroencephalogic pattern that resolved acutely with intravenous diazepam treatment. Since significant morbidity and mortality is associated with unrecognized status epilepticus, electroencephalogic monitoring and a trial of diazepam is indicated in encephalopathic patients with rhythmic electroencephalogic patterns while receiving treatment with ifosfamide.
我们报告了首例非惊厥性癫痫持续状态作为氮芥衍生物异环磷酰胺化疗并发症的病例。我们的患者出现了脑病、上肢肌阵挛以及一种周期性的三相脑电图模式，静脉注射地西泮治疗后急性缓解。由于未识别的癫痫持续状态会导致显著的发病率和死亡率，因此在接受异环磷酰胺治疗的有节律性脑电图模式的脑病患者中，应进行脑电图监测并试用苯二氮卓类药物。
