铜锌超氧化物歧化酶在小鼠嗅黏膜中的免疫细胞化学定位

Immunocytochemical localization of copper-zinc superoxide dismutase in mouse olfactory mucosa.

作者信息

Sakai M, Takeuchi M, Umemura Y, Ueda H, Ohmori T, Ashihara M, Nagatsu I

机构信息

Department of Anatomy, Fujita Health University School of Medicine, Toyoake, Japan.

出版信息

Auris Nasus Larynx. 1993;20(2):113-6. doi: 10.1016/s0385-8146(12)80237-9.

DOI:10.1016/s0385-8146(12)80237-9

PMID:8216045

Abstract

Copper-zinc superoxide dismutase (Cu-Zn SOD) has been localized in mouse nasal mucosa. Immunocytochemical staining using polyclonal antibody against Cu-Zn SOD revealed endogenous Cu-Zn SOD in sustentacular cells in the olfactory area, and in ciliated epithelial cells in the respiratory area of the olfactory mucosa. Since these cells are located in the superficial portion of the olfactory mucosa, Cu-Zn SOD may serve as an intracellular antioxidant.

摘要

铜锌超氧化物歧化酶（Cu-Zn SOD）已定位在小鼠鼻黏膜中。使用抗Cu-Zn SOD多克隆抗体进行的免疫细胞化学染色显示，嗅觉区域的支持细胞以及嗅黏膜呼吸区域的纤毛上皮细胞中存在内源性Cu-Zn SOD。由于这些细胞位于嗅黏膜的表层，Cu-Zn SOD可能作为一种细胞内抗氧化剂发挥作用。