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猕猴子宫外动脉的神经支配及对血管活性药物的反应

Innervation and responses to vasoactive drugs of the extrinsic uterine artery of the macaque.

作者信息

Bell C

出版信息

Cardiovasc Res. 1976 Jul;10(4):482-6. doi: 10.1093/cvr/10.4.482.

DOI:10.1093/cvr/10.4.482
PMID:821612
Abstract

The responses of isolated, perfused uterine arteries from two species of macaques to perivascular nerve stimulation and to vasoactive drugs have been compared with those previously obtained using similar preparations from men. Uterine arteries from nonpregnant monkeys exhibited dilator responses to nerve stimulation and to acetylcholine, and contained few, if any, beta-adrenoceptors. These properties are not shared by the uterine artery of man and cast doubt on the widely held premise that the physiological characteristics of sub-human primates are similar to those of humans.

摘要

对两种猕猴的离体灌注子宫动脉对血管周围神经刺激和血管活性药物的反应,已与先前使用来自人类的类似标本所获得的反应进行了比较。未怀孕猴子的子宫动脉对神经刺激和乙酰胆碱表现出舒张反应,并且即使有也很少含有β-肾上腺素能受体。人类子宫动脉并不具备这些特性,这对广泛持有的前提——非人灵长类动物的生理特征与人类相似——提出了质疑。

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