Ramirez G, Bittle P A, Agosti S J, Dietz J, Colice G L
Department of Internal Medicine, James A. Haley Veterans Administration Hospital, Tampa, FL 33612.
Aviat Space Environ Med. 1993 Sep;64(9 Pt 1):831-8.
The sodium excretory capacity of normal subjects acutely mobilized from sea level to moderately high altitude was compared to native subjects adapted to high altitude living (3,000 meters). This study was conducted in order to provide insights into hormonal adaptations associated with acute mobilization to a hypoxemic environment and to try to determine how these variables could influence the renal handling of a salt load. A standard amount of 5% NaCl solution at a volume of 100 ml/m2 BSA was infused over a 30-min period to all subjects. Urine collections were obtained periodically over the next 3 h. Subjects adapted to moderately high altitude living were able to excrete a salt load faster than unadapted subjects (57.1 vs. 32.9 mmol.m-2.h-1, respectively). No change in plasma atrial natriuretic factor (ANF) concentration in either group of subjects was observed during the salt administration period. Adapted individuals had significantly higher baseline levels of antidiuretic hormone (ADH). The high altitude natives enhanced excretory response to a salt load was not explained by any observed hormonal changes and their lack of increased ADH release to serum osmolar changes was unexplained.
将正常受试者从海平面急性转移至中度高海拔地区后的钠排泄能力，与适应高海拔生活（3000米）的本地受试者进行了比较。进行这项研究是为了深入了解与急性转移至低氧环境相关的激素适应性，并试图确定这些变量如何影响肾脏对盐负荷的处理。向所有受试者在30分钟内输注标准量的100 ml/m²体表面积的5%氯化钠溶液。在接下来的3小时内定期收集尿液。适应中度高海拔生活的受试者比未适应的受试者能够更快地排泄盐负荷（分别为57.1和32.9 mmol·m⁻²·h⁻¹）。在给予盐期间，两组受试者的血浆心钠素（ANF）浓度均未观察到变化。适应的个体抗利尿激素（ADH）的基线水平显著更高。高海拔本地人的增强的盐负荷排泄反应无法通过任何观察到的激素变化来解释，并且他们对血清渗透压变化缺乏ADH释放增加也无法解释。
