D'Amato F R, Pavone F
Instituto di Psicobiologia e Psicofarmacologia, CNR, Roma, Italy.
Behav Neural Biol. 1993 Jul;60(1):79-83. doi: 10.1016/0163-1047(93)90768-d.
The kin selection theory predicts that individuals would behave differently toward one another, depending on their genetic relatedness. Proximate mechanisms have been postulated to exist helping the individual to discriminate what is good or bad for him. Opioids have been discovered to be involved in the mediation of reinforcement, in particular they underlay social emotion. In this study it is shown that pain sensitivity decreased in male mice interacting with siblings following 2 months of separation; this analgesic response was antagonized by naloxone administration. Interaction with unknown and unrelated subjects did not change the nociceptive threshold. These results suggest that interacting with kin is an adaptive situation reinforced, at the neural level, by the release of endogenous opioids.
亲缘选择理论预测，个体会根据基因关联性对彼此表现出不同的行为。人们推测存在近端机制来帮助个体辨别什么对自己有利或有害。已发现阿片类物质参与强化作用的调节，尤其是它们构成了社会情感的基础。本研究表明，雄性小鼠在与分离两个月后的同胞互动时，疼痛敏感性降低；给予纳洛酮可拮抗这种镇痛反应。与陌生且无亲缘关系的个体互动并未改变伤害感受阈值。这些结果表明，与亲属互动是一种适应性情境，在神经层面上由内源性阿片类物质的释放所强化。
