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Biological actions of purines on rat megakaryocytes: potentiation by adenine of the purinoceptor-operated cytoplasmic Ca2+ oscillation.嘌呤对大鼠巨核细胞的生物学作用：腺嘌呤对嘌呤受体介导的细胞质钙离子振荡的增强作用。
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本文引用的文献

1
Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte.大鼠巨核细胞胞质Ca2+振荡的细胞内机制。
J Biol Chem. 1993 Jan 5;268(1):168-74.
2
Interrelationship between growth factor-induced pH changes and intracellular Ca2+.生长因子诱导的pH变化与细胞内Ca2+之间的相互关系。
Proc Natl Acad Sci U S A. 1987 Apr;84(7):1950-4. doi: 10.1073/pnas.84.7.1950.
3
Characterization of inositol trisphosphate receptor binding in brain. Regulation by pH and calcium.脑中肌醇三磷酸受体结合的特性。受pH值和钙的调节。
J Biol Chem. 1987 Sep 5;262(25):12132-6.
4
Activation of sodium-proton exchange is a prerequisite for Ca2+ mobilization in human platelets.钠-质子交换的激活是人类血小板中钙离子动员的一个先决条件。
Nature. 1987;325(6103):456-8. doi: 10.1038/325456a0.
5
Regulation of intracellular pH in human platelets. Effects of thrombin, A23187, and ionomycin and evidence for activation of Na+/H+ exchange and its inhibition by amiloride analogs.人血小板细胞内pH的调节。凝血酶、A23187和离子霉素的作用以及Na⁺/H⁺交换激活及其被氨氯地平类似物抑制的证据。
J Biol Chem. 1986 Oct 5;261(28):13160-7.
6
Na+-H+ and Cl(-)-OH-(HCO3-) exchange in gastric glands.胃腺中的钠-氢和氯-氢氧根（碳酸氢根）交换
Am J Physiol. 1986 Apr;250(4 Pt 1):G524-34. doi: 10.1152/ajpgi.1986.250.4.G524.
7
Ca2+ mobilization can occur independent of acceleration of Na+/H+ exchange in thrombin-stimulated human platelets.在凝血酶刺激的人血小板中，钙离子动员可独立于钠氢交换加速而发生。
J Biol Chem. 1988 Jul 15;263(20):9635-9.
8
Muscarinic activation of ionic currents measured by a new whole-cell recording method.通过一种新的全细胞记录方法测量的毒蕈碱对离子电流的激活作用。
J Gen Physiol. 1988 Aug;92(2):145-59. doi: 10.1085/jgp.92.2.145.
9
Effects of intracellular pH on calcium-activated potassium channels in rabbit tracheal smooth muscle.细胞内pH对兔气管平滑肌钙激活钾通道的影响。
J Physiol. 1990 May;424:445-57. doi: 10.1113/jphysiol.1990.sp018076.
10
Intracellular alkalinization leads to Ca2+ mobilization from agonist-sensitive pools in bovine aortic endothelial cells.细胞内碱化导致牛主动脉内皮细胞中激动剂敏感池的钙离子动员。
J Biol Chem. 1990 Nov 5;265(31):19071-6.

细胞质pH调节大鼠巨核细胞中ATP诱导的钙依赖性钾电流振荡。

Cytoplasmic pH regulates ATP-induced Ca(2+)-dependent K(+)-current oscillation in rat megakaryocytes.

作者信息

Uneyama C, Uneyama H, Takahashi M, Akaike N

机构信息

Division of Pathology, National Institute of Health Sciences, Tokyo, Japan.

出版信息

Biochem J. 1993 Oct 1;295 ( Pt 1)(Pt 1):317-20. doi: 10.1042/bj2950317.

DOI:10.1042/bj2950317
PMID:8216236
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1134856/
Abstract

The effect of cytoplasmic pH (pH(i)) on ATP-induced Ca2+ oscillation of rat megakaryocytes was investigated by the whole-cell patch-clamp technique. Megakaryocytes responded to extracellular ATP and showed the periodic activation of K+ channels, which reflects the oscillation in intracellular free Ca2+ concentration. Intracellular alkalinization by 20 mM NH4Cl resulted in inhibition of the oscillatory response, and intracellular acidification by 20 mM sodium acetate enhanced the response. NH4Cl also inhibited the Ins(1,4,5)P3-induced oscillation. Sodium acetate had no effect on the InsP3-induced oscillation, but enhanced the guanosine 5'-[gamma-thio]triphosphate-induced response. These results indicate that pH(i) modulates the ATP-induced cellular response at least at two points.

摘要

采用全细胞膜片钳技术研究了细胞质pH值（pH(i)）对大鼠巨核细胞ATP诱导的Ca2+振荡的影响。巨核细胞对细胞外ATP有反应，并表现出K+通道的周期性激活，这反映了细胞内游离Ca2+浓度的振荡。20 mM NH4Cl引起的细胞内碱化导致振荡反应受到抑制，而20 mM醋酸钠引起的细胞内酸化则增强了反应。NH4Cl还抑制了Ins(1,4,5)P3诱导的振荡。醋酸钠对InsP3诱导的振荡没有影响，但增强了鸟苷5'-[γ-硫代]三磷酸诱导的反应。这些结果表明，pH(i)至少在两个点上调节ATP诱导的细胞反应。