Sohal R S, Ku H H, Agarwal S
Department of Biological Sciences, Southern Methodist University, Dallas, Texas 75275.
Biochem Biophys Res Commun. 1993 Oct 15;196(1):7-11. doi: 10.1006/bbrc.1993.2208.
The objective of this study was to explore the basis of variations in the life span and metabolic potential, i.e., total amount of energy consumed during life, between different species, in context of the free radical hypothesis of aging. A comparison was made between the house mouse (Mus musculus) and the white-footed mouse (Peromyscus leucopus): the latter has > 2-fold greater life span and metabolic potential than the former. Longer life span and higher metabolic potential of Peromyscus were associated with low rates of mitochondrial O2.- and H2O2 generation, higher activities of catalase and glutathione peroxidase and low levels of protein oxidative damage as well as low susceptibility to oxidative damage in response to experimental oxidative stress. Results support the role of oxidative stress in aging.
本研究的目的是在衰老的自由基假说背景下，探讨不同物种之间寿命和代谢潜能（即生命过程中消耗的总能量）变化的基础。对家鼠（小家鼠）和白足鼠进行了比较：后者的寿命和代谢潜能比前者高出两倍多。白足鼠较长的寿命和较高的代谢潜能与线粒体超氧阴离子和过氧化氢的低生成率、过氧化氢酶和谷胱甘肽过氧化物酶的较高活性、蛋白质氧化损伤的低水平以及对实验性氧化应激的氧化损伤低易感性有关。结果支持氧化应激在衰老中的作用。
