Gedalia A, Zamir S
Pediatric Rheumatology Unit, Soroka Medical Center, Ben Gurion University of the Negev Beer Sheva, Israel.
Pediatr Neurol. 1993 Jul-Aug;9(4):301-2. doi: 10.1016/0887-8994(93)90068-n.
Neurologic involvement in children with familial Mediterranean fever is relatively uncommon and rarely described in the pediatric literature. Although headaches occur frequently, meningitis and convulsions are rare. Thirteen of 101 children with familial Mediterranean fever developed neurologic manifestations. Of these 13 patients, 10 had headaches during acute episodes of the fever. Two patients had convulsions with fever before the age of 5 years; the convulsions and acute episodes recurred at ages 9 and 10 years. Another patient had two episodes of aseptic meningitis followed by convulsive disorder before the diagnosis of familial Mediterranean fever was made; his convulsions were resistant to antiepileptic drugs alone and subsided only when colchicine was added. The possibility of neurologic involvement should be considered in patients with familial Mediterranean fever.
家族性地中海热患儿的神经系统受累相对少见，儿科文献中对此描述甚少。虽然头痛频繁发生，但脑膜炎和惊厥很少见。101例家族性地中海热患儿中有13例出现神经系统表现。在这13例患者中，10例在发热急性期出现头痛。2例患者在5岁前发热时出现惊厥；惊厥和急性期在9岁和10岁时复发。另1例患者在诊断家族性地中海热之前有两次无菌性脑膜炎发作，随后出现惊厥障碍；他的惊厥仅用抗癫痫药物无效，仅在加用秋水仙碱后才缓解。家族性地中海热患者应考虑神经系统受累的可能性。
