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[海葵毒素II对结细胞膜钠通道失活的抑制作用]

[Inhibition of the sodium inactivation of the nodal membrane by anemonia sulcata toxin II].

作者信息

Bergman C, Dubois J M, Rojas E, Rathmayer W

出版信息

C R Acad Hebd Seances Acad Sci D. 1976 May 31;282(21):1881-4.

PMID:821659
Abstract

A neurotoxin (ATX-II) extracted from the tentacles of Anemonia sulcata has been found to interact with the sodium channel of the nodal membrane in myelinated nerve fibres from Rana esculenta. If externally applied at low concentration (Kd = 20 muM), it reduces considerably the rate of inactivation of the sodium conductance without affecting the activation. At such concentrations, the potassium conductance is not affected. If internally applied ATX-II does not affect the membrane conductance.

摘要

从浅裂海葵触须中提取的一种神经毒素(ATX-II)已被发现可与食用蛙有髓神经纤维节段膜的钠通道相互作用。如果以低浓度(解离常数Kd = 20微摩尔)外部施加,它会显著降低钠电导的失活速率,而不影响激活过程。在这样的浓度下,钾电导不受影响。如果内部施加ATX-II,则不会影响膜电导。

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